Skip to main content

SEPTICEMIA

 WHAT IS SEPTICEMIA?

Septicemia, or sepsis, is the clinical name for blood poisoning by bacteria. It is the body's most extreme response to an infection. Sepsis that progresses to septic shock has a death rate as high as 50%, depending on the type of organism involved. Sepsis is a medical emergency and needs urgent medical treatment. Without treatment, sepsis can quickly lead to tissue damage, organ failure, and death.


Septicemia is an infection that occurs when bacteria enter the bloodstream and spread. It can lead to sepsis, the body’s reaction to the infection, which can cause organ damage and even death. Septicemia is more common in people who are hospitalized or have other medical conditions. It requires immediate medical attention and antibiotic treatment.Septicemia, sometimes called blood poisoning, is an infection that occurs when germs get into the bloodstream and spread. The germs are usually bacteria but also can be viruses or fungi.


WHAT CAUSES SEPSIS?

These infections are most often associated with sepsis:

  • Lung infections (pneumonia)

  • Urinary tract infections

  • Skin infections

  • Infections in the intestines or gut

These 3 germs most frequently develop into sepsis are:

  • Staphylococcus aureus (staph)

  • Escherichia coli (E. coli)

  • Some types of Streptococcus.


  • WHO IS AT RISK FOR SEPSIS?

  • n infection can happen to anyone, but there are certain risk factors that put people at higher risk for developing sepsis. These include people with:

    • Chronic medical conditions such as diabetes, cancer, lung disease, immune system disorders, and kidney disease

    • Weak immune systems

    • Community-acquired pneumonia

    • A previous hospitalization (especially hospitalization for an infection)

    Also at risk are:

    • Children younger than 1 year of age

    • Adults age 65 and older

    What are the symptoms of sepsis?

    The following are the most common symptoms of sepsis. However, each person may experience symptoms differently.

    People with sepsis often develop a hemorrhagic rash—a cluster of tiny blood spots that look like pinpricks in the skin. If untreated, these gradually get bigger and begin to look like fresh bruises. These bruises then join together to form larger areas of purple skin damage and discoloration.

    Sepsis develops very quickly. The person rapidly becomes very ill, and may:

    • Lose interest in food and surroundings

    • Become feverish

    • Have a high heart rate

    • Become nauseated

    • Vomit

    • Become sensitive to light

    • Complain of extreme pain or discomfort

    • Feel cold, with cool hands and feet

    • Become lethargic, anxious, confused, or agitated

    • Experience a coma and sometimes death.


    • CAUSES OF SEPSIS

    • Bacteria, viruses, and fungi can enter the bloodstream in many ways, for example:

      The body usually can remove a small number of germs naturally. But if germs continue to grow and spread, that can lead to septicemia.


      DIAGNOSIS AND TREATMENT 

    • The diagnose sepsis, your healthcare provider will look for a variety of physical finding such as low blood pressure, fever, increased heart rate, and increased breathing rate. Your provider will also do a variety of lab tests that check for signs of infection and organ damage. Since some sepsis symptoms (such as fever and trouble breathing) can often be seen in other conditions, sepsis can be hard to diagnose in its initial stages.
    • Sepsis is a life-threatening emergency that needs immediate medical attention. People with sepsis are hospitalized and treatment is started as quickly as possible. Treatment includes antibiotics, managing blood flow to organs, and treating the source of the infection. Many people need oxygen and IV (intravenous) fluids to help get blood flow and oxygen to the organs. Depending on the person, help with breathing with a ventilator or kidney dialysis may be needed. Surgery is sometimes used to remove tissue damaged by the infection.




Comments

Popular posts from this blog

Making sense of cell fate

  Despite the proliferation of novel therapies such as immunotherapy or targeted therapies, radiation and chemotherapy remain the frontline treatment for cancer patients. About half of all patients still receive radiation and 60-80 percent receive chemotherapy. Both radiation and chemotherapy work by damaging DNA, taking advantage of a vulnerability specific to cancer cells. Healthy cells are more likely to survive radiation and chemotherapy since their mechanisms for identifying and repairing DNA damage are intact. In cancer cells, these repair mechanisms are compromised by mutations. When cancer cells cannot adequately respond to the DNA damage caused by radiation and chemotherapy, ideally, they undergo apoptosis or die by other means. However, there is another fate for cells after DNA damage: senescence — a state where cells survive, but stop dividing. Senescent cells’ DNA has not been damaged enough to induce apoptosis but is too damaged to support cell division. While senescen...

MAKING SENSE OF SANGER SEQUENCING

 WHAT IS SANGER SEQUENCING? Sanger sequencing is a method that yields information about the identity and order of the four nucleotide bases in a segment of DNA. Also known also as the “chain-termination method”, it was developed in 1977 by Frederick Sanger and colleagues, and is still considered the gold standard of sequencing technology today since it provides a high degree of accuracy, long-read capabilities, and the flexibility to support a diverse range of applications in many research areas In the mid-1970s, Sanger wasn’t alone in the race to sequence DNA; almost in parallel, two American scientists, Maxam and Gilbert, developed a technique in which DNA is chemically treated to break the chain at specific bases. Following electrophoresis of the cleaved DNA, the relative lengths of the fragments—and thus the positions of specific nucleotides—can be determined and the sequence inferred. This is considered the birth of first-generation sequencing. However, the advent of Sanger’s ...

THE SEROTONIN THEORY OF DEPRESSION

  DEPRESSION Depression, that is major depressive disorder (MDD), is a calamity for individuals and society. If we have not experienced it ourselves, we all know someone who has been struck by this disease. Twenty percent of women and 15 per cent of men suffer at least one episode in their lifetime. In the USA, the lifetime prevalence in the general population is estimated at 16.2 per cent. MDD is characterized by two or more weeks of depressed mood or diminished interest, associated with symptoms such as disturbed sleep, decrease in appetite and libido, psychomotor changes, reduced concentration, excessive guilt and suicidal thoughts or attempts. It is insidious and often recurrent. Although depressive episodes can be treated well with antidepressant medication, structured forms of psychotherapy or a combination of these, the rate of recurrence is high, with each episode raising the probability of a new one by 16 per cent. MDD is the second leading cause of disability worldwide, i...